"The Perfect Drug" is it out there?

What is being done out there? and other trials and medicine your Dr. can do?

Let me tell you what we have done- I can start with 2016 I removed sugar (mostly) from my husbands diet. He had no sugar issues, no diabetes, no high blood sugar, no health issues at all. Matter of fact he was super fit, using creatine working out etc. I did notice however in his 2 cup-a-day coffee habit, he was consuming a BAG of sugar a month, all by himself. I don't drink coffee, and did not use sugar (i was blessed being chunky :)). SO when I told him he was using a bag all by himself, he got rid of it, never looked back, and now drinks black coffee with a mushroom blend mixed it. He also mostly gave up his night sweets which was ice cream or peanut butter and jelly. Diet and exercise seems to have kept major decline away in the last few years for us. I do not think diet caused this disease though- he was always healthy and fit, great labs. I do think that this was there and some procedures "pushed" it forward. He does not have the APOE4 gene and his Dr. did not test for any other genes, but I am seeing new research in that area.

Genes that cause early-onset Alzheimer's disease 

• APP

  Located on chromosome 21, this gene is responsible for producing amyloid precursor protein

• PSEN1

  Located on chromosome 14, this gene is responsible for producing presenilin 1

• PSEN2

  Located on chromosome 1, this gene is responsible for producing presenilin 2

Fast forward to pre Diagnosis, while we waited for our first neuro appointment, I went on Dr. Google and read a lot, read books on amazon and looked at his supplements and from what I see in the spouse groups on FB everyone seems to have a good combo of RX and supplements depending on their spouse's behavior. When Rob went in he was diagnosed with MCI because of EOA (MOCA 19), within 6 months his testing put him solid into EOA stage 4 (MOCA tested a few times 14-17) in 2023. We all feel like it was definitely going on for a few years, but it showed up more as bi polar type behavior, almost drastic narcissistic changes and aggression but not noticeable with anything specific, I kind of thought it was a mid life crisis (again) and he would even out.

What we do that seems to keep him level and with energy and no major mood swings; Rob is probably entering early stage 5 right now in 2025. He is able to do some yard work, golf (but not as good went from 80's to 110), rides his bike in our neighborhood, can workout, but needs help with how to use equipment, he doesn't cook or use stove anymore (I added child locks because it is gas, and well let's just say I go lucky to wake up one morning to a turned on burner), he does not drive any more (could he? maybe, but the traffic and decision making could be fatal). He can read and write, but does not follow show plots and reading is just reading a card or a video, he would not be able to track on a book or learn anything new.

Diet now is a lot of nuts and berries and Greek yogurt for snacks. Hard boiled eggs and bacon every breakfast, no drinking (but he never was a drinker as an adult, well 30 and under he did. We only drinks water and our dinners and lunches vary, but usually blue apron prepared meals or I meal prep for week with chicken/fish/shrimp/scallops, brown rice, quinoa, we don't really engage with meat and potatoes a lot anymore. Lots of salads and roasted veges in our diet.

RX's

Donepezil 10mcg nightly

Synthroid 25mcg daily am

Lexapro 25mg daily am

Rob's Supplements:

B12

Fatty15 https://fatty15.com/- really good omega, I was using to fix my Cholesterol numbers and it worked quickly, so I started him on it too.

D3 1000 https://a.co/d/8dLk2FQ

Cognium Memory supplement https://a.co/d/i8GlNOq

Lions Mane- He is doing a coffee supplement https://zplantmagic.com/products/lion-s-milk-shroomed-lion-s-mane-mushroom-blend?selling_plan=3420094623

What else is available out there (2025)

Google prompt is "Alzheimer's Trials near me"

There are Injections to slow down progression (they have a chance for a brain bleed) we said no, Dr supported us with that, since he was doing so well. I have followed a few people who are on them, and they are not seeing improvement nor any major decline, so that is good hope for now.

There is a Viagra trial- not sure I'd sign up for that one-----

Light Therapy

Plasmapheresis- this one is about 10K a month, so i wouldn't call that a trial, that is a travesty that they are charging that much for something unproven. BUT i will say this procedure saved my mother who got Guillian-Barre in the 90's.

(Side note this is a disease that can happen after Co-Vid or Flu shot)

Guillain-Barré Syndrome (GBS) 

Guillain-Barré syndrome (GBS) is a rare autoimmune disorder where the body's immune system mistakenly attacks the peripheral nerves, which connect the brain and spinal cord to the rest of the body. This damage can lead to muscle weakness, numbness, tingling, and paralysis

Aricept

And many more-

What do I think pushed his Alzheimer's forward, I feel like it was a combination of things. He had a retinal tear in 2016 that had emergency surgery on, then a colonoscopy that he did not come out of sedation for at least 45min, and lastly the Pz shot that his employer mandated. I feel his decline showed up after that last thing which I am not against taking it, I just feel like his body fought it differently and reacted differently.

"The Perfect Drug" by Nine Inch Nails